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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Child
Concept Child Day Care Centers
Concept Child, Preschool
Concept Treatment Outcome
Concept Gene-Environment Interaction
Concept Parents
Concept Adult Children
Academic Article Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial.
Academic Article Broad and narrow heritabilities of quantitative traits in a founder population.
Academic Article The genetic dissection of complex traits in a founder population.
Academic Article Sex-specific genetic architecture of whole blood serotonin levels.
Academic Article ITGB3 shows genetic and expression interaction with SLC6A4.
Academic Article Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?
Academic Article CFTR mutations and reproductive outcomes in a population isolate.
Academic Article Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Academic Article Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Academic Article Estimation of variance components of quantitative traits in inbred populations.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites.
Academic Article HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.
Academic Article Maternal microchimerism protects against the development of asthma.
Academic Article Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Host genetic variation influences gene expression response to rhinovirus infection.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article Asthma Genetics in the Post-GWAS Era.
Academic Article Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Grant Prenatal Origins of Asthma
Grant Rhinovirus Infections and Asthma in Children and Adolescents
Academic Article Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Academic Article Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.
Academic Article Immune development and environment: lessons from Amish and Hutterite children.
Academic Article Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes.
Academic Article Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Academic Article Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study.
Academic Article Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Academic Article FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Academic Article Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes.
Academic Article Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels.
Academic Article Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Academic Article Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Academic Article Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Academic Article DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Academic Article Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Academic Article A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Grant Airway inflammation and HLA-G in asthma
Grant Positional Cloning of a 6p-linked Asthma Gene
Grant Molecular Genetic Studies of Fertility in the Hutterites
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant Training of Junior Faculty for Careers in Omics of Lung Diseases
Grant CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Grant THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
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